The Coeliac/Gluten Sensitivity Profile is a specialised blood test designed to assess your immune response to gluten and support the investigation of coeliac disease and gluten-related disorders. By analysing 3 important immunology biomarkers, this profile helps identify antibodies commonly associated with coeliac disease and provides valuable information for further clinical assessment.
A professional phlebotomy blood sample is required to ensure accurate laboratory analysis.
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If you regularly experience digestive discomfort, bloating, abdominal pain, unexplained fatigue, or other symptoms after eating gluten-containing foods, this profile can provide important information about your immune response to gluten.
The test measures specific antibodies that are commonly elevated in people with coeliac disease and may also assist in the assessment of gluten sensitivity. While blood test results alone cannot confirm a diagnosis, they are an essential part of the diagnostic process and can help determine whether further investigations, such as specialist referral or intestinal biopsy, may be appropriate.
This profile is suitable for individuals who:
For the most reliable results, you should continue eating a normal gluten-containing diet before testing unless advised otherwise by your healthcare professional.
This profile measures key immune system antibodies associated with gluten-related conditions. Together, these biomarkers help assess whether your immune system is reacting abnormally to gluten and support the investigation of coeliac disease.
Biomarkers Included:
Gliadin Antibodies (IgG) (Deamidated)
This test measures antibodies produced against deamidated gliadin peptides, which are closely associated with immune reactions to gluten. Elevated levels may support the investigation of coeliac disease, particularly in individuals with symptoms suggestive of gluten intolerance. It may also provide additional diagnostic information alongside other coeliac antibody tests.
Immunoglobulin A (IgA)
Immunoglobulin A is an important antibody involved in protecting the digestive and respiratory systems. Measuring total IgA helps determine whether your immune system is producing normal levels of this antibody and ensures that coeliac antibody tests relying on IgA can be accurately interpreted. Low IgA levels may require additional testing using alternative antibody markers.
Tissue Transglutaminase IgA (tTG-IgA)
The Tissue Transglutaminase IgA antibody is one of the primary laboratory markers used when investigating coeliac disease. Elevated levels suggest an immune response directed against tissue transglutaminase following gluten exposure and may indicate the need for further clinical assessment. This test is widely recognised as one of the most useful first-line blood tests for suspected coeliac disease.
Choose your preferred blood test and arrange a convenient appointment.
Our qualified phlebotomist safely collects your blood sample professionally.
Your sample is analysed by our accredited partner laboratory.
Receive clear reports with professional clinical interpretation and guidance.
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